Original Research Paper

Synthesis And Antimicrobial Evaluation Of Some Novel Isatin Derivatives

Abstract :

Present day challenge of managing microbial infection is ever increasing on account of many factors, out of which emergence of microbial resistance is topmost. Microorganisms are responsible for a number of diseases in human and other animals. As per a report, infectious disease is responsible for 16 million deaths every year worldwide and a lot of these are avoidable. The high level of antimicrobial resistance is a global public health concern. Resistance to potent and effective drugs such as cephalosporins, fluoroquinolones, and carbapenems is a particular concern, as is multidrug resistance. India occupies highest position in the world, in infectious disease list. Antimicrobial agents are considered to be miracle drugs that are the leading weapons in combating infectious disease caused by microbes like bacteria, viruses, and fungi. Antimicrobial resistance (AMR), or drug resistance, is the ability of microbes, including bacteria, fungi, parasites, and viruses, to grow in the presence of antimicrobial agent that previously treated them effectively. Statistics of World Health Organisation (WHO), show that 490000, people developed MDR-TB, in 2016, globally. The drug resistance is also causing hindrance in fight against HIV and malaria. The study also indicates that people with methicillin resistance Staphylococcus aureus is 64% more proven to death than people infected with non resistant microbes.Experts are constantly working hard to devise newer compounds to meet this challenge. Many pharmacophore have the potential as antimicrobial and anticancer agent. Pyrimidine, like Isatin also reported to possess versatile activity such as antimicrobial, anticancer, antifungal, anti-malarial, antiviral and anti-tubercular.

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