Original Research Paper

Efficacy Of Salivary Trefoil Factor 3 As Biomarker In Chronic Periodontitis Patients.

Dr. Dandu Siva Sai Prasad Reddy, Dr. Kotu Nagavenkata Sai Praveen, Dr. Sameeulla Shaik, Dr. Navya Teja Tungala, Dr. Poornima Parvathala

Abstract :

Background: Biomarkers are the molecules that help in evaluating the status of disease and the prognosis of treatment. One such molecule that gained popularity as a biomarker among chronic periodontitis patients in recent days is Trefoil Factor 3(TFF3). TFF3 was evaluated in saliva, but its clinical significance and correlation with periodontal pathogens among periodontitis patients have never been investigated.Material & Methods: Saliva and supra, infra gingival plaque samples were collected from 30 periodontitis and 30 non-periodontitis individuals. Enzyme-linked immunosorbent assay was used to estimate the salivary levels of TFF3. The polymerase chain reaction was advocated for analyzing periodontal pathogens from plaque samples. Results: Reduced salivary TFF3 levels were observed in chronic periodontitis patients, with a negative correlation between several periodontal pathogens and TFF3 levels.Conclusion: Our study results suggest a negative correlation between inflammatory mediators and salivary TFF3 levels. Thus, the estimation of TFF3 can be considered as a potential biomarker in evaluating disease states among periodontitis patients.

Cite This Article :

EFFICACY OF SALIVARY TREFOIL FACTOR 3 AS BIOMARKER IN CHRONIC PERIODONTITIS PATIENTS., Dr. Dandu Siva Sai Prasad Reddy, Dr. Kotu Nagavenkata Sai Praveen, Dr. Sameeulla Shaik, Dr. Navya Teja Tungala, Dr. Poornima Parvathala, INTERNATIONAL JOURNAL OF PURE MEDICAL RESEARCH : Volume-8 | Issue-7 | July-2023

Article :

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