Original Research Paper

Co Relation Of Cardiac Autonomic Neuropathy And Glycosylated Haemoglobin In Type 2 Diabetes Patients

Abstract :

Fifty patients of type 2 diabetes mellitus were studied to assess the correlation between cardiac autonomic dysfunction and glycosylated haemoglobin (HbA1c). Five simple bedside tests based on cardio-vascular reflexes (heart rate response to standing, heart rate response to valsalva manoeuvre, heart rate variation during deep breathing, blood pressure response to standing and blood pressure response to sustained hand grip) were carried out and glycosylated haemoglobin of each patient was measured. Cardiac autonomic dysfunction was found in 56% diabetics and raised glycosylated haemoglobin was found in 76% patients.Incidence of parasympathetic autonomic neuropathy was 56 % in comparison to sympathetic neuropathy ,which was 20 %, suggesting that parasympathetic pathway may be more sensitive for detection of cardiac autonomic neuropathy. Highest incidence of cardiac autonomic neuropathy has been observed between age group of 51 to 60 and as the duration of diabetes increases the incidence of cardiac autonomic neuropathy also increases. Significant correlation of 73.9% has been observed between cardiac autonomic neuropathy and glycosylated haemoglobin.

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