Original Research Paper

A Study On The Impact Of Supplemental Bicarbonate On The Development Of Chronic Kidney Disease

Abstract :

Background- One of the major public health issues, chronic kidney disease (CKD) is characterized by structural and functional abnormalities around the kidney.Objectives- To analyze the effect of oral supplementation of bicarbonate on the progression of CKD.Methods-A double blind Randomized controlled trial study conducted at Tertiary care centre. Patients with CKD who were visiting hospital were considered as the study subjects. A total of 60 patients participated in the study. Patients were randomly grouped into two groups through block randomization. The first group of patients received oral sodium bicarbonate, whereas the second group of patients was on standard therapy without oral sodium bicarbonate supplementation. SPSS was used for analysis.Results- Group 1 consisted of 31 subjects, out of which 18 (69.7%) were males and 13 (30.3%) were females. Group 2 included 29 patients, of which 16 (73.53%) were males and 13 (26.47%) were females. Among the causes for CKD, hypertension was the most common cause followed by diabetes seen in almost 50% of cases. The mean weight of groups 1 and 2 was 58.12 and 61.96 kg, respectively, whereas the mean height of groups 1 and 2 was 161.70 and 161.82 cm, respectively. The mean bicarbonate levels of groups 1 and 2 patients were 16.62 and 16.84 mEq/L, respectively. After 6 months, the bicarbonate level of group 1 significantly increased to 18.02 mEq/L, which was further increased to 19.77 mEq/L after 9 months (p

Cite This Article :

Article :